Intermittent fasting (IF) and time-restricted eating (TRE) have gained significant attention as dietary interventions for health promotion and disease prevention. This comprehensive review examines the metabolic effects, potential benefits for longevity, and practical applications in precision nutrition approaches.

Autophagy is a cellular quality control mechanism that becomes dysregulated with aging. Recent evidence suggests that exercise can stimulate autophagy pathways, potentially contributing to its anti-aging effects. This review explores the molecular mechanisms linking exercise-induced autophagy to healthy aging.

Poor sleep quality has been associated with increased cardiovascular disease risk. This 15-year longitudinal study of 45,000 participants examines the relationship between sleep metrics and cardiovascular outcomes, providing insights for longevity-focused health interventions.

The gut microbiome plays a crucial role in healthy aging through its influence on inflammation, metabolism, and neural function. This study identifies key microbial signatures associated with successful aging and cognitive preservation in centenarians.

Chronic stress accelerates cellular aging through telomere shortening. This research demonstrates that stress resilience training can protect telomere length and potentially slow biological aging processes, offering new therapeutic targets for longevity interventions.

Caloric restriction extends lifespan across species, but adherence remains challenging. This review examines caloric restriction mimetics - compounds that activate similar pathways without dietary restriction - and their potential as anti-aging therapeutics.